The specific objectives of ENPRA in five areas are:
(i) Hazard Identification: Characterize a panel of commercially available ENP carefully chosen to address the relevant hazards, properties and potential mechanisms;
(ii) Dose-response Assessment: Assess the hazards of these ENP by means of in vitro toxicology tests based on:
- five body systems - pulmonary; hepatic; renal; cardio-vascular; and developmental systems;
- for five endpoints - oxidative stress; inflammation and immune-responses; genotoxicity; fibrogenecity; and developmental toxicity.
(iii) Verify the in vitro findings with validation tests
(iv) Exposure and Risk Assessment - Use data from this project and other sources to:
- Model exposure and the exposure-dose response relationships by means of mathematical modelling such as PBPK and QSAR-like methods, and extend these deterministic models into probabilistic models
- Conduct the risk assessment with uncertainty analysis;
(v) Risk Management: Develop and implement a strategy for dissemination to maximize the anticipated high impact of our findings.